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(33896531) Phenytoin accumulation, as well as an increased free fraction of phenytoin, may tend to cause phenytoin toxicity
and to reduce kidney disease risk in people with type 2 diabetes and chronic kidney disease
Bunck MC, Cornr A, Eliasson B, et al
This phenomenon is further illustrated by results from a randomized, open-label mechanistic trial in patients with T2DM, which demonstrated that lixisenatide, with a half-life of 2 4 hours, had a significantly greater effect than liraglutide in delaying in gastric emptying and curtailing postprandial glucose excursions following a standardized solid breakfast (156)
The eligible patients signed written informed consent prior to participation in the study
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