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Langeveld M, Tan CY, Soeters MR, Virtue S, Watson LP, Murgatroyd PR, Ambler GK, Vidal-Puig S, Chatterjee KV, Vidal-Puig A

A compound with a 30-minute half-life will reach undetectable plasma concentrations faster than one with a 3-hour half-life

Capitalizing on this understanding, nutritional interventions target OA through a multi-tiered approach: (1) Upstream regulation using anti-inflammatory nutrients (e.g., omega-3 fatty acids, polyphenols) to quell systemic inflammation and oxidative stress (10)

Aquaculture 529, 735684

This conceptual integration is especially relevant in PD, in which hallmark features of oxytosis/ferroptosis including oxidative stress, iron accumulation, and glutathione depletionare prominently observed (Lewerenz et al., 2018)

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