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One significant mechanism involves the production of immunosuppressive factors, with MDSCs secreting high levels of arginase-1 (Arg-1) [11], inducible nitric oxide synthase (iNOS) [12], and reactive oxygen species (ROS) [13], all of which play key roles in dampening T cell activity

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Higher pH inhibits somatostatin release, which increases gastrin release, causing hypergastrinemia [52]

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