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The small number of subjects in this study is a caveat, and analysis of a larger number of subjects in the context of a clinical trial would be required to confirm these results and assess efficacy of the compounds
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Nicotinamide N-methyltransferase transfers a methyl group from S-adenosyl methionine to nicotinamide, producing 1-methylnicotinamide
GPx activity depends on GSH concentration, which acts as a hydrogen donor and is oxidized to GSSG in the process (22)
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