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When the list price of a drug is announced, insurance companies and Pharmacy Benefit Managers (PBMs) step in to negotiate with the drug manufacturers

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it is mainly produced by the mutated form of the enzyme isocitrate dehydrogenase (mutIDH1/2) [23] and it is structurally similar to -ketoglutarate (-KG), the physiological product of the wild-type IDH

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Epitalon is the spelling used in FDAs 2026 assessment and many scientific publications