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Molecular Profile (CAS 910463-68-2) Storage, Handling, and Reconstitution of Semaglutide Store lyophilized powder at -20 C, desiccated, protected from light

In a recent Phase 2 study presented in June 2025, combining it with semaglutide (the active ingredient in Wegovy) led to remarkable outcomes for participants with obesity: An average weight loss of 22% over 72 weeks (compared to 16% with semaglutide alone) About 93% of that loss coming from fat mass, with minimal impact on lean muscle A 58% drop in visceral fat (versus 36% with semaglutide alone) All achieved without requiring dietary or exercise modifications This stands out because typical weight-loss drugs, like GLP-1 agonists, often result in losing both fat and musclea downside, since muscle boosts metabolism and supports overall health as we age

The decision marks a reversal for Caremark, which last summer became the only major pharmacy benefit manager to exclude Zepbound while continuing to cover rival Novo Nordisks Wegovy