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[in Italian] Altomare E, Colonna P, DAgostino C, et al

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Cullin-RING ligases (CRLs) are the largest family of E3 ubiquitin ligases, which have essential role in controlling numerous cancer-relevant proteins ubiquitylation and proteasomal degradation 1

Unlike peptides that enhance general health or growth hormone, FOXO4-DRI removes harmful cells, making it a more direct approach to rejuvenation at the cellular level

Nevertheless, a meta-analysis of 15 randomized controlled trials (RCTs) demonstrated that probiotic supplementation significantly shortened whole-gut transit time, improved stool consistency, and increased stool frequency (392)

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