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The biggest one is stacked GI side effects - nausea, vomiting, diarrhea, and constipation - because both compounds slow digestion
Minoxidil clearance depends on UGT1A-mediated glucuronidation and SULT1A1-mediated sulfation [1][2]
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Other relevant interactions: Colchicine (used for gout) may affect B12 absorption with long-term use Chloramphenicol (rarely used antibiotic) may blunt the haematological response to B12 treatment Monitoring considerations: Patients taking loop or thiazide diuretics require careful monitoring when initiating B12 therapy in severe deficiency, due to the risk of hypokalaemia during rapid cell production
Biochem Pharmacol 76:15441553
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