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The redox status has been suggested to regulate stem cell self-renewal and differentiation, and accumulating evidence indicates that stem cells undergo self-renewal in the environment with low ROS levels, while ROS levels increase in differentiated stem cells [117, 118]

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2025;26(1):e13841

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The safety profile of retatrutide in the MASLD subset was similar to the obesity trial population, with no hepatoxicity signals reported in either population at 48 weeks