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The metabolites of chronic overnutrition, such as hyperglycaemia and non-esterified FAs (NEFAs), disrupt with the activation of the INSR and its downstream IRS-1/PI3K/Akt2 pathway
The more energy required for a chemical activity, the more ATP molecules must be spent
For most patients, minimal preparation is required before receiving a Vitamin B12 shot
In the Wegovy HD piece I flagged the persistent gap between what semaglutide does in obesity and what it does in obesity plus type 2 diabetes: 20.7% versus 14.1%
A 1,200-calorie diet of processed food will produce very different health outcomes than a 1,200-calorie diet of whole foods, even if the scale shows similar numbers
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