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Tikkanen I, Narko K, Zeller C, et al

Native IGF-1 exists predominantly bound to IGF-binding proteins (IGFBPs) in circulation, which sequester the growth factor and limit its bioavailability to target tissues

However, in the process of squelching free radicals these nutrients transform from a reduced state to an oxidized state, lose their spare electron (now molecularly unstable) and ultimately become free radicals themselves

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They advised the panel to vote no