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Additional modulators, including Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4), which promotes PUFA incorporation into membrane phospholipids, and lipoxygenases (LOXs), further influence ferroptosis sensitivity by regulating lipid composition and oxidation dynamics (90, 91)

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Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)