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Days 3 to 7: If side effects are going to occur at this dose, they typically manifest by now

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Contact your GP or healthcare provider if: Nausea is severe, persistent, and prevents you from eating or drinking adequately for more than 24 hours You experience repeated vomiting (more than 34 times in 24 hours) or cannot keep down fluids You notice signs of dehydration: dark urine, dizziness, dry mouth, reduced urination, or feeling faint when standing You develop severe or persistent abdominal pain, particularly if accompanied by fever or vomiting You experience symptoms of pancreatitis: severe upper abdominal pain radiating to the back, nausea, vomiting, and fever You notice a lump in your neck, persistent hoarseness, or difficulty swallowing Seek immediate medical attention (call 999 or attend A&E) if you experience: Severe allergic reactions: difficulty breathing, swelling of face or throat, severe rash Symptoms suggesting gallbladder problems: severe right upper abdominal pain, yellowing of skin or eyes (jaundice), fever with abdominal pain Acute breathing difficulties Severe dehydration with confusion, rapid heartbeat, or inability to pass urine Your prescriber may need to adjust your dose if side effects are intolerable

BioDrugs, 12(2), 139-157

In head-to-head studies, tirzepatide outperformed semaglutide in terms of weight loss and improvements in risk factors related to metabolism and heart disease