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(Risk Factors) 8

Among them, the most typical is the chemokine Leukotriene B4 (LTB4), the increased expression of which causes recruitment of neutrophils, ATMs, T cells, and B cells, which increase expression of pro-inflammatory cytokines, eventually leading to the development of eWAT inflammation and obesity (132) ( Figure 3 )

Accordingly, the mechanistic link between lactate-mediated pH changes and iron-dependent ferroptosis remains inadequately characterized

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