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Thirty years of preclinical data, a mechanism that makes biological sense, and early human signals that are encouraging this is not a fringe or pseudoscientific compound
(2014) reported significantly reduced mRNA levels of SOD, CAT, and glutathione peroxidase (GPX) in oligodendrocytes from the white matter of patients with MDD in post-mortem analysis
Drugs, environmental toxins, byproducts of metabolism
doi: 10.3389/fendo.2025.1683419 Received 12 August 2025 Revised 04 December 2025 Accepted 30 December 2025 Published 23 January 2026 Volume 16 - 2025 Edited by Claudia Lagranha, Federal University of Pernambuco, Brazil Reviewed by Lei Zhao, China Medical University, China Michihiro Takahashi, Takahashi Psychiatric Clinic, Japan Sundararajan Mahalingam, University of Nebraska Omaha, United States Rodolfo Nunes, Federal University of Ceara, Brazil Updates Copyright 2026 Doval-Caballero, Ferreira-Hermosillo, Eugenio-Ponce, Garca-Senz, Ibarra-Salce, Tenorio-Rojo, Luna-Avila, Gete-Palacios, Prez-Hernndez, Rojas-Miln, Lpez-Cruz and Mndez-Hernndez
Bhattacharyya, S., Saha, S., Giri, K., Lanza, I
The implication is that clinicians managing menopausal women on GLP-1 therapies should consider hormonal status not as a separate clinical question but as a variable that directly shapes metabolic treatment outcomes
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