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Protocols are entirely community-developed, with doses extrapolated from cell culture bioactivity data and molecular weight calculations
Fewer say they got a GLP-1 from a medical spa or aesthetic medical center (9%)
Cubero, M
(A reminder: GLP-1s were developed originally to help regulate blood sugar for people with diabetes, and then started to get prescribed off-label because of their weight loss effects.) It's not just weight loss, though
The STEP trials evaluating semaglutide 2.4 mg for weight management reported gallbladder disorders in approximately 1.6-2.6% of participants receiving the medication versus 0.7-1.2% receiving placebo
Glutamate then binds to NMDA and AMPA receptors on NPY/AgRP neurons resulting in an additional level of activated NPY and AgRP gene expression
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