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The needle dulls after a single puncture through a vial stopper, and a second use introduces both a contamination risk and a less comfortable injection

The appetite suppression typically begins within 2448 hours of the first dose, though the effect strengthens over the first 48 weeks of treatment

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Underlying medical conditions may blunt treatment response

A dose of 500 to 1,000 mg of ginger root extract taken 30 minutes before meals can meaningfully reduce nausea frequency and severity

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