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We reran the GWAS additionally adjusting for HDRS 17 scores at each time point to eliminate the effects linked to depression severity

The synergistic activation of GIP and GLP-1 receptors has been recognized as a promising therapeutic approach in the treatment of T2D and obesity (17, 18)

Preclinical studies suggest that GLP-1 receptor activation in the mesolimbic dopamine system appears to modulate dopamine signaling, which is central to the rewarding effects of alcohol and other addictive substances

Zepbound is FDA-approved for weight loss and chronic weight management in adults with obesity or overweight

Serum metabolomics as a novel diagnostic approach for disease: A systematic review