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For comfort and compliance it would be highly desirable to have effective alternative means to administer peptides, such as by the oral route

Creatine to increase strength and muscle mass, L-carnitine to burn fat and reduce fatigue

The potential for small molecules to inhibit these pathways and non-selectively inhibit GHR signaling needs to be considered in small molecule discovery studies

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The common adverse events included headache, dyspnea, and tiredness