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Most compounds specifically targeting cancer NADPH metabolism are in preclinical studies, thus there are still challenges to address before these compounds enter the clinic
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This leads to a faster breakdown of glutathione (GSH), a key antioxidant
Furthermore, reactive nitrogen species (RNS)[192] are also associated with the S-nitrosylation of intracellular target proteins
*Correspondence: Antonio Di Sabatino, [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
