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Statements Author contributions MEHK: Conceptualization, Writing original draft, Writing review and editing

Regardless, Ozempic will only be covered for Type 2 diabetes, not weight loss

Key insight: Retatrutides glucagon-mediated increase in energy expenditure means the body is simultaneously eating less AND burning more a combination that may explain the superior efficacy signal seen in early trials

The most common side effects are gastrointestinal, including nausea (affecting 20-40% of patients), vomiting, diarrhoea, constipation, and abdominal discomfort

10.1021/acsnano.4c10382 74 ZhaoJ.WangB.YanM.LiuY.ZhaoR.WangX.et al (2025)

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