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Excess adipose tissue, particularly visceral fat, is metabolically active and can disrupt normal hormone production

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In this double-blind, placebo-controlled randomised clinical trial of 17,604 adults, semaglutide reduced the incidence of cardiovascular death, myocardial infarction and stroke (HR 0.80

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Discussion This study shows that early discontinuation of GLP-1 RAs is associated with higher risks of cardiovascular events during treatment