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[1] [4] The timeline for GLP-1 medications to "kick in" varies depending on which therapeutic effect you're measuring and the specific medication used

Ozeki, Y., Masaki, T., Kamata, A., Miyamoto, S., Yoshida, Y., Okamoto, M., Gotoh, K., & Shibata, H

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PubMed PMID: 27186127

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Additionally, patients experiencing severe vomiting or diarrhea should be monitored for dehydration and acute kidney injury