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8 In animal models the full protein has shown benefit in dermal wounds, corneal injury, and cardiac repair after infarction, where it can activate epicardial progenitor cells and promote cardiomyocyte survival
Atherosclerosis progression, as a chronic inflammatory mechanism, is characterized by immune system dysregulation associated with increased pro-inflammatory cytokine production, including interleukin 6 (IL-6), tumor necrosis factor- (TNF-), and IL-1, as well as pattern recognition receptor proteins like CRP (170, 261267)
As noted above, mTOR signaling has emerged as a key control point for B cell functions 35
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