The GLP-1R Agonist, Exendin-4 Modifies Secretory Currents and Gut Permeability As Ex-4 modifies the excitability of the SMP and this is the neural regulator of gut absorpto-secretory function, Ussing chambers were used to examine the impact of the GLP-1R agonist on colonic absorpto-secretory currents
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1315 For example, elevated glucose concentrations activate the transcription factor carbohydrate response element-binding protein, which indirectly promotes GLP-1 secretion through regulation of target genes in intestinal L cells