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However, differences in trial design and patient backgrounds, such as baseline A1C and concurrent use of metformin, make direct comparisons challenging

For GLP-1 users, weight-management endpoints (body fat, waist circumference, energy intake) are the most directly relevant available evidence, given that GLP-1-specific RCT data is absent across the entire probiotic category

This evaluation is critical for safe polypharmacy management

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Their protective effects are mediated through activation of NRF2 and GPX4, highlighting the therapeutic relevance of these pathways in AD

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