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Introduction In addition to the ongoing opioid crisis, cocaine use disorder continues to present as a public health issue and for which there are currently no Food and Drug Administration-approved pharmacotherapies

While some GLP-1 receptor agonists have FDA-approved cardiovascular risk reduction indications, tirzepatide does not currently have this indication, though cardiovascular outcome trials are ongoing

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In a retrospective analysis of 6050 patients with adult-onset GH deficiency, a significantly increased prevalence of diabetes has been reported (58)

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What this means: Insurance coverage will be critical Manufacturer savings programs will likely be available Access will be a significant barrier for many people Cost-effectiveness will be debated extensively The superior results might justify the cost for insurance companies