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What happens if I stop sermorelin but continue Zepbound? Discontinuing sermorelin while maintaining Zepbound returns you to standard GLP-1 monotherapy appetite suppression and weight loss continue, but the body composition advantage (enhanced muscle preservation, improved fat oxidation) diminishes over 24 weeks as growth hormone levels return to baseline
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Rao SSC et al
Two studies were carried out in healthy subjects to investigate the effects of semaglutide on the pharmacokinetics of four therapies that are commonly co-administered with GLP-1RAs [14,15,16] and are characterised by differing properties of solubility and intestinal permeability [17]
Real-world data tells you what happens with everyone else
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