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A cytoprotection-associated effect may be more visible under injury or stress conditions than in basal, unstressed cells

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Tirzepatide may lead to more pronounced gastrointestinal problems due to its dual action, while Retatrutides side effects seem slightly milder based on initial studies

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(2021) demonstrated that MOTS-c levels decline with age in both mice and humans, and that exogenous MOTS-c administration improved physical capacity in aged mice without observable toxicity over a 2-week treatment window [5]

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