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Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)
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The aldosterone induced Na + reabsorption indirectly influences water retention as water movement follows Na + movement across the membrane as a means to maintain osmolarity
Many people start with weekly shots, then move to monthly maintenance once levels are stable
