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Mechanistically, it influences gene networks involved in tissue remodeling and exerts protective antioxidant and anti-inflammatory actions, partly through TGF- signaling and regulation of metalloproteinases

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doi: 10.1136/heartjnl-2019-316376 [PubMed] [CrossRef] [Google Scholar] Cosentino F., et al., 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

Patients with one clearly defined injury need the local approach

Using a buffered ascorbyl glucoside or ascorbyl phosphate, or separating applications by time, reduces this risk

TB-500 works systemically and thus does not need to be administered to a specific target