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While dura mater B cells, including immature B2 subsets, originate primarily from skull bone marrow, antigen-experienced B cells in the peripheral blood can infiltrate the meninges during aging [120]
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In conclusion, BARI-STEP, a randomized, placebo-controlled trial investigating the use of once-weekly semaglutide 2.4 mg in a post-bariatric patient population with a suboptimal clinical response, demonstrates that semaglutide 2.4 mg in patients with a suboptimal clinical response results in substantial, clinically relevant body weight reduction, and improvements in metabolic health and quality of life
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