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Genetic instruments for GLP-1R activation were selected based on associations with traits linked to drug target effects, such as body mass index (BMI) and glycated hemoglobin (HbA1c)

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In the glycolytic pathway, NAD+ facilitates the catalytic reactions of Glyceraldehyde-3-phosphate dehydrogenase (GADPH) and lactate dehydrogenase (LDH)

These effects may potentially provide a novel therapeutic solution for stroke, imparting specific beneficial effects on the CNS (i.e., for reperfusion, the amelioration of neuronal damage and, thereby, recovery without memory, locomotor, and coordination disturbances, and the expression of the particular genes in the hippocampus)