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CV: cardio-vascular EMA: European Medicines Agency FDA: Food and Drugs Administration GLP-1 RA: glucagon-like peptide 1 receptor agonist HbA1c: glycated haemoglobin HR: hazard ratio MACE: major adverse cardiovascular events NAFLD: non-alcoholic fatty liver disease NASH: non-alcoholic steatohepatitis T2D: type 2 diabetes The authors gratefully acknowledge Professor Giuliana Arcidiacono, English and Anglo-American language PhD, University of Catania, for the language revision of the manuscript

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Moderate alcohol consumption is defined as no more than 2 drinks/day for men and no more than 1 drink/day for women