In liver injury of hepatitis virus infection, transgenic mice expressing HBsAg exhibit the generation of oxidative stress and DNA damage, leading to the progression of hepatic fibrosis and carcinogenesis (Hagen et al., 1994
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After pre-conditioning in the presence or absence of 50 nM Exendin-4 for additional 18 hours, culture medium was changed to serum-free DMEM containing 1 mM sodium pyruvate, without glucose and sodium bicarbonate
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As a combined medicinal treatment for viral infections such as COVID-19 or influenza, administration of GSH or NAC in conjunction with established anti-viral treatment has been found to improve lymphocyte response, reduce pro-inflammatory cytokines and reduce cellular oxidative injury (Tieu et al., 2023)