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It targets not just one, but several core mechanisms of aging simultaneously: telomere maintenance, epigenetic regulation, oxidative stress resilience, immune recalibration, and circadian rhythm restoration [1]

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At one point, Sophia pulled up an old photo on her phone of her mother when she was still using drugs: Massarones face looked hollow, her eyes glassy and veiled by heavy mascara

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From a drug-development perspective, METRNL illustrates the limitations of receptor-centric paradigms

4 MELAS and epilepsy The pathogenesis of MELAS is associated with gene mutations, vascular disease, nitric oxide (NO) dysregulation, and energy deficiency