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In contrast to the expected results, the clearance, and consequently, the AUC of caffeine, was even decreased in cirrhotic mice, suggesting increased metabolism (Supplementary Figure S4)

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Neurology 45:15941601 Mandal PK, Saharan S, Tripathi M, Murari G (2015) Brain glutathione levelsa novel biomarker for mild cognitive impairment and Alzheimers disease