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Liu, Z., Vincken, J., & De Bruijn, W

It is best supported by academic literature for: Topical vitamin C has been shown to help neutralize oxidative stress from UV and pollution, helping to improve photoaging and hyperpigmentation when used consistently

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They also recommend contacting the healthcare provider when nausea, vomiting, diarrhea, or constipation persists despite basic management

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Once reconstituted, that stability window narrows significantly, which is why technique and storage are so important in research environments