severe or persistent upper abdominal pain should prompt urgent medical assessment [10] [11] Dehydration and acute kidney injury (AKI): gastrointestinal fluid losses can lead to dehydration, which may precipitate AKI, particularly in those with pre-existing renal impairment or those taking nephrotoxic medicines Delayed gastric emptying: this may affect the absorption of orally administered medicines, including contraceptive pills and thyroid replacement therapy [11] Injection site reactions: redness, bruising, or discomfort at the subcutaneous injection site Heart rate changes: increases in resting heart rate have been noted with GLP-1 class agents [14] [15] Hypoglycaemia: particularly if used alongside insulin or sulphonylureas Potential pancreatitis risk: a class concern with GLP-1 receptor agonists
GLP-1 receptor agonists can trigger nausea by acting on CNS pathways, which is why some providers believe B6 may help mitigate these effects
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It's worth noting that GLP-1 receptor agonists typically have a low risk of causing hypoglycaemia in adults when used alone, but any transfer to the infant could potentially influence blood sugar regulation in vulnerable newborns
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doi: 10.23736/S0026-4784.20.04615-8 164 SantanamNKavtaradzeNMurphyADominguezCParthasarathyS
