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(PubMed) Nathan DM, Davidson MB, DeFronzo RA, et al
Cell migration and wound-closure assays (such as scratch assays in fibroblast or endothelial cell cultures) are standard in vitro models for studying this combination's proposed tissue-repair pathway effects, typically comparing single-compound versus combined-compound treatment conditions
Pregnant or breastfeeding women safety unknown Cancer patients or those with tumor history due to VEGF promotion, angiogenesis could theoretically support tumor growth Autoimmune disorders while BPC-157 is generally anti-inflammatory, immune modulation can vary by individual Angiogenic peptides may pose theoretical risks in neoplastic conditions by promoting blood vessel formation
Topical KPV and PEPITEM-derived tripeptides have been studied for direct application to affected skin
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