Carregando, aguarde
Future research is warranted to examine potential differential effects among specific GLP-1RA medications
1 Thus, numerous studies have used biotechnology to extend the half-life of GLP-1 RAs, with strategies including amino acid sequence substitution, fatty acid conjugation with a linker, fusion of albumin or the IgG fragment crystallizable (Fc) region (Figure 1)
However, there are a couple of key differences that researchers should be aware of before designing their research project
Although EMPEROR-R enrolled patients with and without type 2 diabetes, the primary outcome of the trial (a composite of CV death and hospitalization for HF) was almost identical in both groups, suggesting that the different population didnt affect the results, at least for the primary outcome
When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before