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For ongoing authorization renewals, periodic BMI documentation may be required to demonstrate continued medical necessity

Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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[2] [1] The risk of hypoglycaemia is meaningfully increased when retatrutide is used alongside insulin or sulfonylureas, consistent with the established class precedent for GLP-1 receptor agonists (as documented in the SmPCs for tirzepatide and semaglutide)

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Gubras GAN DIO-MASH model: Advancing preclinical MASH research At the heart of this shift is the need for robust and clinically relevant preclinical MASH models