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As an active metabolite synthesized by intestinal microbiota, the increased level of TMAO is associated with increased risks of CAD and all-cause mortality (130, 131)
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Persistent fatigue may indicate inadequate B-vitamin cofactor status
Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
The effect of protein intake in CKD is controversial, but high protein intake has been associated with hyperfiltration, increased acid excretion, and potentially, a decline in kidney function.3 4 However, protein intake on a well-formulated ketogenic diet (WFKD) is moderate to effectively permit nutritional ketosis
