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doi:10.3390/cells10050993 71
At present, seven trials have currently been reported for GLP-1 receptor agonists which include ELIXA (Evaluation of LIXisenatide in Acute coronary syndrome
22 In the PIONEER-6 trial evaluating oral semaglutide, among patients with T2DM, the CV risk profile was not inferior to that of patients in the placebo group but it did not show superiority of this agent to placebo
Beyond GLP-1: efficacy and safety of dual and triple incretin agonists in personalized type 2 diabetes care-a systematic review and network meta-analysis
Analysis of commercial claims data covering approximately 50 million insured lives found GLP-1 users experienced: 44% fewer major cardiovascular-related hospitalizations 69% improvement in medical spend growth among diabetes-related GLP-1 users over 30 months 37% improvement in medical spend growth among weight-loss GLP-1 users over 18 months Researchers have also observed positive trends related to inflammatory conditions, cardiovascular disease, and other chronic health concerns
To put Lillys 25.5% in perspective, previous pivotal trials for Tirzepatide, such as SURMOUNT-1 and SURMOUNT-5, showed weight loss of 20.9% and 20.2% respectively over 72 weeks
