The same thing can happen after bariatric surgery as your body drops pounds
In the kidney, dual GLP-1R/GIPR stimulation attenuates MCP-1, IL-6, and tumor necrosis factor (TNF)- expression and down-regulates SGLT2 messenger ribonucleic acid (mRNA), potentially reinforcing natriuresis and glycosuria when GLP-1RA are combined with SGLT2 inhibitors [26]
This viral-induced dysmetabolism creates a powerful synergy with the underlying drivers of SLD (Schinzari et al., 2015)
doi: 10.1186/s12866-025-04201-2 177 LidbergK.PilhedenS.Relloso Ortiz de UriarteM.JonssonA.-B
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Regular monitoring of nutritional status, hydration, weight trajectory, and functional capacity can help maximize the benefits of GLP-1 therapy while minimizing nutrition-related complications in older adults