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CpG cytosines in these regions are not methylated and are more readily available to transcription factors such as the GC cassette, the cAMP-responsive element (CRE) [23], the sterol regulatory element (SRE), the GCAAT sequence (potential nuclear factor Y binding site), promoter elements and downstream promoter elements (DPE)

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However, depending on the location, adjacent parenchyma may contain pressure atrophy of the hepatic cords of the liver, fibrosis, hemosiderin deposition, proliferation of bile ducts, or periportal lymphocytic infiltration