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It includes 1-5 intramuscular or subcutaneous injections of 1000 mcg crystalline cyanocobalamin daily, followed by oral doses of 1000-2000 mcg/day Parenteral administration should be reserved for those with significant neurological symptoms NICE guideline: Vitamin B 12 deficiency in over 16s: diagnosis and management: Malabsorption as the confirmed or suspected cause of vitamin B 12 deficiency: Offer replacement to people if: lifelong intramuscular vitamin B12 Autoimmune gastritis is the cause They have had a total gastrectomy They have had a complete terminal ileal resection If the person has a vitamin B 12 deficiency because of malabsorption that is not caused by autoimmune gastritis, or a total gastrectomy or complete terminal ileal resection (for example, malabsorption caused by coeliac disease, partial gastrectomy or some forms of bariatric surgery): Offer vitamin B 12 replacement and Consider intramuscular instead of
Age You are more likely to be B12 deficient if you are over the age of 65, as the body becomes less efficient at absorbing nutrients as you go on in life
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This decreases production of intrinsic factor and secretion of hydrochloric acid in the stomach, two things that affect your body's absorption of B12
Reticulocyte count
A complete blood count (FBC) reveals overall health markers and can identify anaemia, which affects approximately 25-30% of individuals experiencing hair loss [2]
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