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doi:10.1056/NEJMoa2032183 Lempesis IG, Liu J, Dalamaga M

In the years since its initial approval, real-world evidence has confirmed its safety and effectiveness

The expression of the enzyme cyclooxygenase-2 (COX2) was markedly upregulated in diabetic kidney tissues

Sub-analyses from trials like LEADER (liraglutide) and REWIND (dulaglutide) have shown modest reductions in high-sensitivity C-reactive protein (hsCRP) and other inflammatory biomarkers among patients treated with these agents

Among the major complications are cardiovascular disease, kidney disease, diabetic foot ulcers, diabetic retinopathy, and neurological disorders