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Antioxidant mechanisms include enhanced expression of molecules that can modulate ROS accumulation by both enzymatic and nonenzymatic meansGlutathione (GSH) is an antioxidant that acts as a free radical scavenger and a detoxifying agent in cells

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[7] This two-enzyme description applies to mammals and many other organisms, but it is not universal

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(3) Al-Samerria S, Radovick S

Moderately and severely affected individuals have enzymes with dysfunctional catalytic sites, rendering it unable to participate in detoxification reactions