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diabetes-nave patients have no prior activity for metformin, GLP-1s, or other diabetes medicines such as insulins, DPP-4s, SGLT-2s, etc

The key degradation gene tnaA was first interrupted in E

A history of pancreatitis is a key medical exclusion because GLP-1 medications can increase the risk of this painful and serious condition

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The SUSTAIN-6 trial , published in the New England Journal of Medicine in 2016, found that participants taking semaglutide had a higher rate of diabetic retinopathy complications compared to placebo (3.0% versus 1.8%)